PFT enters Week 6 at 45-33-1 after an 8-6-1 Week 5, then lays out predictions for all 14 games on the schedule.
Seattle gets a 24-21 edge over Denver on Thursday night, Jacksonville is picked 20-17 over Houston in London, and Kansas City 30-17 over the Chargers could deepen pressure on coach Mike McDaniel.
Among the strongest calls, the Rams are forecast to rout Arizona 41-17 and San Francisco to beat Washington 38-17, while Buffalo, Green Bay and Indianapolis are also backed to win.
The analysis flags several swing factors across the slate, including Caleb Williams potentially returning for Chicago, Philadelphia trying to survive injuries after its London trip, and Aaron Rodgers' form helping Pittsburgh.
Four teams are idle in Week 6 — the Bengals, Dolphins, Lions and Vikings — as the remaining 28 teams play through a 14-game slate.