Exin Therapeutics Uses AI to Inject 250 Nanolitres in Epileptic Mouse as Opus 5.5 Refused
Updated
Updated · news.lavx.hu · Oct 31
Exin Therapeutics Uses AI to Inject 250 Nanolitres in Epileptic Mouse as Opus 5.5 Refused
3 articles · Updated · news.lavx.hu · Oct 31
Summary
Oct. 28 surgery at Exin Therapeutics had an Anthropic Sonnet-based agent choose a gene therapy vector, brain target and 250-nanolitre dose, then steer a robotic rig to inject an epileptic mouse.
Given 19 candidate vectors, the agent pulled coordinates from three research papers and monitored the rig camera for bleeding, while a licensed veterinarian approved each irreversible step and held a physical kill switch.
Safety rules barred the AI from performing the craniotomy or changing critical settings, and the team had to manually fix the agent's code during the operation.
Opus 5.5 refused the biological experiment and older Opus 5 would only draft a plan, underscoring how unusual the live procedure was; Exin said the mouse recovered well afterward.
Ethicists and clinicians said handing every decision in a risky procedure to AI muddies accountability, adding to broader concerns over animal experimentation and surgical AI failures.