Buffalo opened new Highmark Stadium with a 41-31 win over Detroit, improving to 2-0 after scoring touchdowns on its first four possessions.
Josh Allen drove the offense with 248 passing yards, 72 rushing yards and five total touchdowns, while James Cook added 135 yards and the clinching late score.
A 27-7 lead shrank to 34-24 after Detroit scored on four of five midgame drives, exposing a Bills defense that still looks unsettled despite four sacks.
Amon-Ra St. Brown caught 9 passes for 142 yards and 2 touchdowns for the Lions, but Buffalo limited Jahmyr Gibbs to 52 rushing yards on 16 carries.
The result reinforced Buffalo's early offensive surge under Joe Brady, though allowing 31 points again kept defensive concerns in view.