NFL Releases Week 2 Picks and Odds, Led by Bills -5 vs Lions in Thursday Opener
Updated
Updated · USA TODAY · Sep 15
NFL Releases Week 2 Picks and Odds, Led by Bills -5 vs Lions in Thursday Opener
3 articles · Updated · USA TODAY · Sep 15
Summary
Week 2 opens Thursday with Buffalo favored by 5 points over Detroit as the Bills debut new Highmark Stadium in the slate’s marquee matchup.
16 games carry early BetMGM lines and expert picks, with several matchups framed around fast starts or early trouble as teams chase 2-0 records or try to avoid 0-2.
35 of 288 teams since 1990 recovered from an 0-2 start to make the playoffs before the 2025 season, underscoring the pressure on early losers.
Other notable spreads include 49ers -13.5 over the Dolphins, Chiefs -6.5 against the Colts and Rams -7 versus the Giants on Monday night.