Shinshu Scientists Find Pterostilbene Cuts Muscle Fat in Mouse Cells via PPARδ
Updated
Updated · ScienceDaily · Sep 12
Shinshu Scientists Find Pterostilbene Cuts Muscle Fat in Mouse Cells via PPARδ
3 articles · Updated · ScienceDaily · Sep 12
Summary
Shinshu University researchers found pterostilbene—the blueberry and grape compound—most strongly reduced abnormal lipid buildup in cultured C2C12 mouse muscle cells while normal cell growth and differentiation continued.
Cell tests showed the compound did not block fatty-acid entry; instead it increased glycerol release and switched on genes tied to fatty-acid oxidation, indicating stored fat was being broken down for energy.
Mechanism studies linked the effect to PPARδ: pterostilbene raised the protein’s level by slowing its degradation through the ubiquitin-proteasome pathway rather than directly activating the receptor.
The work, published September 1 in Food Bioscience volume 83, targets myosteatosis—a buildup tied to inactivity, aging and high-fat diets—but remains limited to cultured mouse cells, with animal and human studies still needed.