Five people were killed and five injured when 21 Air Flight 7598, a Boeing 767-300 flying for Amazon Air from San Juan, overran a Miami International Airport runway shortly before 2 p.m. Sunday.
The freighter left the usable runway at 112 knots, struck vehicles beyond the airfield and caught fire; three injured people were in critical condition, and the two pilots were trapped in the aircraft.
More than 200 emergency personnel responded within seconds, flights were briefly halted, and two of Miami's four runways later reopened as crews still worked on a fuel leak.
The FAA and NTSB both opened investigations, with NTSB Chair Jennifer Homendy heading to Miami for a Monday briefing; weather, touchdown point, speed and other factors remain under review.
Amazon said it was heartbroken and would cooperate fully; the crash hit one of the busiest U.S. travel weekends at a major international freight hub served by Amazon's 100-plus-aircraft network.