Notre Dame pulled away from a 13-10 halftime deficit to beat Wisconsin 41-13 at Lambeau Field in the 13th Shamrock Series.
A 28-3 second half drove the win, with the Irish holding Wisconsin to 1.4 yards per rush over the final 30 minutes.
CJ Carr went 19-for-29 for 239 yards and spread completions to nine receivers, while Aneyas Williams ran for 90 yards and two touchdowns.
Drayk Bowen led the defense with nine tackles, Jaiden Ausberry and Adon Shuler added seven each, and DJ McKinney contributed in his first action for Notre Dame.
The result opened Notre Dame's season with a statement win over Wisconsin after halftime adjustments flipped a sluggish start.