Baltimore squandered a 3-1 lead and lost 9-7 after Chicago ripped off eight straight runs, pushing the Orioles to 42-51 and deeper out of the playoff race.
Dean Kremer triggered the swing by allowing three fifth-inning homers—two to Pete Crow-Armstrong—and Grant Wolfram helped the Cubs break it open with a wild seventh that ended on Seiya Suzuki’s three-run shot.
Jackson Holliday went 4-for-4, Tyler O’Neill hit two homers, and Coby Mayo added another as Baltimore scored four late runs but never brought the tying run to the plate in the ninth.
The defeat followed Tuesday’s series-opening loss, leaving the Orioles trying to avoid a sweep at home with Trevor Rogers set to start the finale.